• Internal medicine · Jan 2022

    Case Reports

    Successful Elimination of SARS-CoV-2 Following Vaccination with BNT162b2 after Prolonged Viral Infection in an Immunocompromised Lymphoma Patient.

    • Masao Hagihara, Yui Imai, Tomoyuki Uchida, Shin Ohara, Morihiro Inoue, Tomiyuki Sugi, and Keiko Mitamura.
    • Department of Hematology, Eiju General Hospital, Japan.
    • Intern. Med. 2022 Jan 1; 61 (14): 2215-2219.

    AbstractA 52-year-old man with mantle cell lymphoma treated with bendamustine and rituximab developed prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Despite elevated titers of anti-spike IgG antibody, protracted pancytopenia persisted for more than six months. Finally, the anti-SARS CoV-2 vaccine, BNT162b2, was administered, which improved his blood cell count and eliminated the virus. The increased anti-spike IgG titer and lymphocyte count after vaccination suggested that both humoral and cellular immunity acted in coordination to eliminate the virus.

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