• Hee Young Kim, Jung Hwan Jo, ChungJin WooJWDepartment of Oral Medicine, Seoul National University Dental Hospital, Seoul, Republic of Korea.Department of Oral Medicine and Oral Diagnosis, School of Dentistry, Seoul National University, Seoul, Republic of Korea.Dental Research Institu, and Ji Woon Park.
• Department of Oral Medicine, Seoul National University Dental Hospital, Seoul, Republic of Korea.
• Medicine (Baltimore). 2022 Jul 22; 101 (29): e29400e29400.

AbstractObstructive sleep apnea (OSA) is a chronic condition accompanied by repeated obstruction of the upper airway during sleep despite respiratory efforts, resulting in intermittent hypoxemia, altered sleep structure, and sympathetic activation. Previous studies have shown a significant association between OSA and general health issues such as cardiovascular diseases, endocrine disorders, neurocognitive function decline, and poor quality of life. Continuous positive airway pressure (CPAP) has been considered as the first line treatment for OSA. However, accumulating evidence supports the role of oral appliance (OA) therapy, including mandibular advancement devices, as an alternative option for snoring and OSA patients who do not comply with or refuse CPAP usage. Despite a generally favorable outcome of OA therapy for OSA related respiratory indices, studies focusing on the impact of systemic effects of OA therapy in OSA patients are relatively scarce compared with the extensive literature focusing on the systemic effects of CPAP. Therefore, this article aimed to provide an overview of the current evidence regarding the multisystemic effects of OA therapy for OSA.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

23 keywords...

hide…