• Jae Yeon Lee and Sang Beom Han.
• Department of Ophthalmology, Kangwon National University College of Medicine, Kangwon National University Hospital, Chuncheon, Korea.
• Medicine (Baltimore). 2022 Jul 22; 101 (29): e30041e30041.

RationaleTo report a case of bilateral transient corneal edema presumably associated with adenovirus-vectored coronavirus disease 2019 (COVID-19) vaccination that resolved with eye drops treatment.Patient ConcernsA 55-year-old Asian woman presented with sudden onset of bilateral visual disturbance developed 6 days after immunization with an adenovirus-vectored COVID-19 vaccine (AstraZeneca, London, United Kingdom). She underwent uneventful cataract surgery in right and left eyes 2 months ago and maintained good visual acuity bilaterally. Slit-lamp examination showed bilateral mild corneal edema that was confirmed with anterior segment optical coherent tomography. Anterior chamber and vitreous were clear bilaterally. Both fundi were normal.DiagnosesThe patient was diagnosed with corneal edema following adenovirus-vectored COVID-19 vaccination.InterventionsShe was prescribed with prednisolone acetate 1% eye drops bilaterally.OutcomesTreatment with topical steroid for 2 weeks resulted in resolution of the corneal edema and improvement of the visual acuity bilaterally.LessonsThis case suggests that transient corneal edema can develop following adenovirus-vectored COVID-19 vaccination. Prompt ophthalmologic evaluation and treatment may improve the corneal edema.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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