• Erika Christina Gouveia E Silva, Ana Carolina Basso Schmitt, Caroline Gil de Godoy, Amislaine Cristina Gambeta, CarvalhoCelso Ricardo Fernandes deCRFDepartment of Physical Therapy, Speech Therapy, and Occupational Therapy, Faculdade de Medicina, Universidade de São Paulo, SP, Brazil., Carolina Fu, Clarice Tanaka, JuniorCarlos ToufenCTDivisão de Pneumologia, Instituto do Coração (InCor), Faculdade de Medicina FMUSP, Universidade de Sao Paulo, São Paulo, SP, Brazil., CarvalhoCarlos Roberto Ribeiro deCRRDivisão de Pneumologia, Instituto do Coração (InCor), Faculdade de Medicina FMUSP, Universidade de Sao Paulo, São Paulo, SP, Brazil., and José Eduardo Pompeu.
• Department of Physical Therapy, Speech Therapy, and Occupational Therapy, Faculdade de Medicina, Universidade de São Paulo, SP, Brazil. Electronic address: erikacgc@usp.br.
• Clinics (Sao Paulo). 2022 Jan 1; 77: 100075.

ImportanceDespite ambulation capacity being associated with a decreased level of physical activity and survival may be influenced by the functional capacity, studies have not addressed the association between ambulation capacity and death in patients hospitalized by COVID-19.ObjectiveTo verify the functional, clinical, and sociodemographic risk factors associated with in-hospital death in individuals with severe COVID-19.MethodsIt is a cohort retrospective study performed at a large tertiary hospital. Patients 18 years of age or more, of both sexes, hospitalized due to severe COVID-19 were included. Cases with dubious medical records and/or missing essential data were excluded. Patients were classified according to their ambulation capacity before the COVID-19 infection. Information regarding sociodemographic characteristics, in-hospital death, total hospital stays, Intensive Care Unit (ICU) stays, and the necessity of Mechanical Ventilation (MV) were collected from medical records and registered in a RedCap database. Multiple logistic regression analysis was used to identify possible factors associated with the in-hospital death rate.ResultsData from 1110 participants were included in the statistical analysis. The median age of the patients was 57 (46‒66) years, 58.42% (n = 590) were male, and 61.73% (n = 602) were brown or black. The case fatality rate during hospitalization was 36.0% (n = 363). In-hospital death was associated with ambulation capacity; dependent ambulators (OR = 2.3; CI 95% = 1.2-4.4) and non-functional ambulation (OR = 1.9; CI 95% = 1.1-3.3), age [older adults (OR = 3.0; CI 95% = 1.9‒4.), ICU stays (OR = 1.4; CI 95% = 1.2‒1.4), immunosuppression (OR = 5.5 CI 95% = 2.3‒13.5) and mechanical ventilation (OR = 27.5; CI 95% = 12.0-62.9).Conclusion And RelevanceDecreased ambulation capacity, age, length of ICU stay, immunosuppression, and mechanical ventilation was associated with a high risk of in-hospital death due to COVID-19.Copyright © 2022 HCFMUSP. All rights reserved.

19 keywords...

hide…