• Medicina · Jul 2022

    Review Case Reports

    Pulmonary Alveolar Proteinosis and Pregnancy: A Review of the Literature and Case Presentation.

    • Brindusa Ana Cimpoca Raptis, Anca Maria Panaitescu, Gheorghe Peltecu, Nicolae Gica, Radu Botezatu, Mihaela Roxana Popescu, Anca Macri, Ana Constantin, and Bogdan Pavel.
    • Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
    • Medicina (Kaunas). 2022 Jul 23; 58 (8).

    AbstractPulmonary Alveolar Proteinosis (PAP) is a rare, usually autoimmune, disease, where surfactant accumulates within alveoli due to decreased clearance, causing dyspnea and hypoxemia. The disease is even more rare in pregnancy; nevertheless, it has been reported in pregnant women and can even appear for the first time during pregnancy as an asthma-like illness. Therefore, awareness is important. Similarly to many autoimmune diseases, it can worsen during pregnancy and postpartum, causing maternal and fetal/neonatal complications. This paper offers a narrative literature review of PAP and pregnancy, while illustrating a case of a pregnant patient with known PAP who developed preeclampsia in the third trimester but had an overall fortunate maternal and neonatal outcome.

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