• Ke Li, Shuping Sun, Zhanyou Xue, Sufen Chen, Chunyang Ju, Dongmei Hu, Xiaoyu Gao, Yanhong Wang, Dan Wang, Jianjun Chen, Li Li, Jing Liu, Mingjie Zhang, Zhihua Jia, Xun Han, Huanxian Liu, Mianwang He, Wei Zhao, Zihua Gong, Shuhua Zhang, Xiaoxue Lin, Yingyuan Liu, Shengshu Wang, Shengyuan Yu, and Zhao Dong.
• Department of Neurology, the First Medical Center, Chinese PLA General Hospital, 100853, Beijing, China.
• J Headache Pain. 2022 Jul 30; 23 (1): 92.

BackgroundThere have been a few studies regarding the pre-attack symptoms (PAS) and pre-episode symptoms (PES) of cluster headache (CH), but none have been conducted in the Chinese population. The purpose of this study was to identify the prevalence and features of PAS and PES in Chinese patients, as well as to investigate their relationships with pertinent factors.MethodsThe study included patients who visited a tertiary headache center and nine other headache clinics between January 2019 and September 2021. A questionnaire was used to collect general data and information about PAS and PES.ResultsAmong the 327 patients who met the CH criteria (International Classification of Headache Disorders, 3rd edition), 269 (82.3%) patients experienced at least one PAS. The most common PAS were head and facial discomfort (74.4%). Multivariable logistic regression analysis depicted that the number of triggers (OR = 1.798, p = 0.001), and smoking history (OR = 2.067, p = 0.026) were correlated with increased odds of PAS. In total, 68 (20.8%) patients had PES. The most common symptoms were head and facial discomfort (23, 33.8%). Multivariable logistic regression analysis showed that the number of triggers were associated with increased odds of PES (OR = 1.372, p = 0.005).ConclusionsPAS are quite common in CH patients, demonstrating that CH attacks are not comprised of a pain phase alone; investigations of PAS and PES could help researchers better understand the pathophysiology of CH.© 2022. The Author(s).

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