• Kyung-A Ko, Jin-Young Park, Jung-Seok Lee, Byoung Seok Ye, Ui-Won Jung, Seong-Ho Choi, and Jae-Kook Cha.
• Department of Periodontology, Research Institute of Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, Korea.
• Yonsei Med. J. 2022 Aug 1; 63 (8): 783-789.

PurposeThe aim of this study was to investigate the association between the changes in masticatory function and cognitive impairment by analyzing longitudinal data of older Korean patients.Materials And MethodsPatients aged over 60 years with dental records between 2005 to 2010 (baseline; T1) and 2014 to 2020 (follow-up; T2) were selected in a single medical center. Based on the dementia diagnosis after T2, the cohort was classified into two groups, the dementia group (n=122) and the control group (n=366). Changes in masticatory function were calculated using the total functional tooth unit (T-FTU) in both groups. The incidence of tooth extraction (%) and the subsequent rehabilitation during the observation period were also evaluated.ResultsIn the dementia group, T-FTU significantly decreased from T1 to T2 (9.81±2.78 to 9.11±3.16, respectively, p=0.008), while no significant change was observed in the control group. During the mean observation period of 9 years, significantly more teeth were extracted and neglected to be prosthetically restored in the dementia group than in the control group. Regression analysis revealed that the number of missing teeth neglected [odds ratio (OR)=1.195, 95% confidence interval (CI)=1.025-1.393, p=0.023] and previous alcohol consumption (OR=4.445, 95% CI=1.831-1.795, p=0.001) were the most significant risk factors of dementia.ConclusionThere might be a causative relationship between the neglected missing dentition and the onset of dementia.© Copyright: Yonsei University College of Medicine 2022.

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