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Rev Assoc Med Bras (1992) · Jul 2022
Human enteroviral infection in fibromyalgia: a case-control blinded study.
- Basant K Puri, Gary S Lee, and Armin Schwarzbach.
- University of Winchester - Winchester, United Kingdom.
- Rev Assoc Med Bras (1992). 2022 Jul 1; 68 (7): xxx.
ObjectiveThis study aimed to test the hypothesis that fibromyalgia is associated with a human enteroviral infection.MethodsVenous peripheral blood samples from 27 patients fulfilling the American College of Rheumatology revised diagnostic criteria for fibromyalgia and from 26 age- and sex-matched controls, who underwent immunofluorescence assays for coxsackievirus A7 IgG, coxsackievirus B1 IgG, coxsackievirus A7 IgA, coxsackievirus B1 IgA, echovirus IgG, and echovirus IgA. These immunological tests were performed blind to group status.ResultsThere were no significant differences between the patient and control groups in respect of positive results for coxsackievirus A7 IgG (p=0.467), coxsackievirus B1 IgG (p=0.491), coxsackievirus A7 IgA (p=0.586), coxsackievirus B1 IgA (p=0.467), echovirus IgG (p=0.236), and echovirus IgA (p=1).ConclusionsThe results of this systematic study do not support the hypothesis that fibromyalgia is associated with infection by a human enterovirus.
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