• Medicina clinica · Jan 2023

    Case Reports Observational Study

    Effectiveness of nebulized hypertonic saline in patients with bronchial hypersecretion.

    • Almudena González-Montaos, Cristina Ramos-Hernández, Irene Lojo-Rodríguez, Marta Núñez-Fernández, and Alberto Fernández-Villar.
    • Servicio de Neumología, Hospital Álvaro Cunqueiro; Área sanitaria de Vigo; Neumo I+i; Instituto de Investigación Biomédica de Galicia Sur (IISGS), Vigo, Pontevedra, España. Electronic address: almudena.gonzalez.montaos@sergas.es.
    • Med Clin (Barc). 2023 Jan 5; 160 (1): 232623-26.

    IntroductionNebulized hypertonic saline (HS) improves quality of life and reduces exacerbations in patients with cystic fibrosis. It is unknown if it would offer the same benefits in other hypersecretory pathologies.MethodsRetrospective observational study. Patients who passed the tolerance test and started HS 5.8% with one year of follow-up were included. Clinical and healthcare parameters were quantified in the year before and after the start of treatment.Results101 patients, 60.4% women, 65years (95%CI: 62.4-67.9): 82 (81.2%) bronchiectasis, 6 (5.9%) COPD, 2 (2%) asthma, 1 (1%) ILD, and 10 (9.9%) other causes. There was a reduction in bronchorrhea (91.1% vs 75.2%), recurrent infections (57.4% vs 22.8%) and cycles of antibiotic therapy (1.54 vs 0.55), as well as an increase in FEV1 (1881ml vs. 1942ml) and a decrease in visits to primary care (2.94 vs. 1.1), emergencies (0.36 vs. 0.17) and hospitalizations (0.17 vs. 0.17). 06). 73 patients (72.3%) presented an adequate tolerance.ConclusionNebulization of HS 5.8% in patients with bronchial hypersecretion is safe and has a remarkable clinical and healthcare impact.Copyright © 2022 Elsevier España, S.L.U. All rights reserved.

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