• Phillip E Vlisides, Graciela Mentz, Aleda M Leis, Douglas Colquhoun, Jonathon McBride, Bhiken I Naik, Lauren K Dunn, Michael F Aziz, Kamila Vagnerova, Clint Christensen, Nathan L Pace, Jeffrey Horn, Kenneth Cummings, Jacek Cywinski, Annemarie Akkermans, Sachin Kheterpal, Laurel E Moore, and George A Mashour.
• Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan; Center for Consciousness Science, University of Michigan Medical School, Ann Arbor, Michigan.
• Anesthesiology. 2022 Oct 1; 137 (4): 434445434-445.

BackgroundThe relationship between intraoperative physiology and postoperative stroke is incompletely understood. Preliminary data suggest that either hypo- or hypercapnia coupled with reduced cerebrovascular inflow (e.g., due to hypotension) can lead to ischemia. This study tested the hypothesis that the combination of intraoperative hypotension and either hypo- or hypercarbia is associated with postoperative ischemic stroke.MethodsWe conducted a retrospective, case-control study via the Multicenter Perioperative Outcomes Group. Noncardiac, nonintracranial, and nonmajor vascular surgical cases (18 yr or older) were extracted from five major academic centers between January 2004 and December 2015. Ischemic stroke cases were identified via manual chart review and matched to controls (1:4). Time and reduction below key mean arterial blood pressure thresholds (less than 55 mmHg, less than 60 mmHg, less than 65 mmHg) and outside of specific end-tidal carbon dioxide thresholds (30 mmHg or less, 35 mmHg or less, 45 mmHg or greater) were calculated based on total area under the curve. The association between stroke and total area under the curve values was then tested while adjusting for relevant confounders.ResultsIn total, 1,244,881 cases were analyzed. Among the cases that screened positive for stroke (n = 1,702), 126 were confirmed and successfully matched with 500 corresponding controls. Total area under the curve was significantly associated with stroke for all thresholds tested, with the strongest combination observed with mean arterial pressure less than 55 mmHg (adjusted odds ratio per 10 mmHg-min, 1.17 [95% CI, 1.10 to 1.23], P < 0.0001) and end-tidal carbon dioxide 45 mmHg or greater (adjusted odds ratio per 10 mmHg-min, 1.11 [95% CI, 1.10 to 1.11], P < 0.0001). There was no interaction effect observed between blood pressure and carbon dioxide.ConclusionsIntraoperative hypotension and carbon dioxide dysregulation may each independently increase postoperative stroke risk.Copyright © 2022, the American Society of Anesthesiologists. All Rights Reserved.

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