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- Masanobu Yukutake, Tsuyoshi Sekito, Ichiko Yamakita, Hideki Itakura, Koki Kabu, and Shinji Nagata.
- Department of Gastroenterology, Hiroshima City Asa Citizens Hospital, Japan.
- Intern. Med. 2023 Apr 15; 62 (8): 115111551151-1155.
AbstractPemigatinib is a fibroblast growth factor receptor inhibitor (FGFRi) approved for the treatment of patients with previously treated biliary tract cancer with FGFR2 fusion. Although infrequent, ocular toxicity manifested as serous retinal detachment (SRD) has been observed and is regarded as a serious side effect. We herein report the case of a 54-year-old woman with unresectable cholangiocarcinoma-initiated pemigatinib after failure of gemcitabine plus S-1 (GS). Although the patient experienced repeated SRD after pemigatinib, dose interruption and dose reduction of pemigatinib from 13.5 mg to 9 mg, and from 9 mg to 4.5 mg led to complete recovery of SRD, and continued tumor shrinkage.
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