• Internal medicine · Mar 2023

    Review Case Reports

    A Case of Possible Chronic Graft-versus-host Disease in the Central Nervous System Manifesting as Cerebellar Ataxia after Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia.

    • Kae Takahashi, Takayuki Katayama, Takaya Ichikawa, Satomi Matsuoka, Yasutaka Kakinoki, Makoto Yoneda, Akio Kimura, Satoshi Koyama, and Osamu Yahara.
    • Department of Neurology, Asahikawa City Hospital, Japan.
    • Intern. Med. 2023 Mar 1; 62 (5): 779786779-786.

    AbstractA 44-year-old woman was admitted to our hospital with a fever, dizziness, and gait disturbance after undergoing allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia followed by graft-versus-host disease. She presented with cerebellar ataxia, nystagmus, and numbness of the lower extremities. Brain magnetic resonance imaging and perfusion scintigraphy showed progressive cerebellar involvement. Cerebrospinal fluid tests showed mildly elevated protein and IgG levels without pleocytosis. Anti-ganglioside antibodies were detected, but their levels did not follow the patient's clinical course. The patient did not respond sufficiently to steroids or other immunotherapies. We herein report the clinical characteristics of this case and a literature review.

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