• Chiara Rosignoli, Raffaele Ornello, Agnese Onofri, Valeria Caponnetto, Licia Grazzi, Alberto Raggi, Matilde Leonardi, and Simona Sacco.
• Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
• J Headache Pain. 2022 Aug 11; 23 (1): 100100.

AbstractMigraine is a complex condition in which genetic predisposition interacts with other biological and environmental factors determining its course. A hyperresponsive brain cortex, peripheral and central alterations in pain processing, and comorbidities play a role from an individual biological standpoint. Besides, dysfunctional psychological mechanisms, social and lifestyle factors may intervene and impact on the clinical phenotype of the disease, promote its transformation from episodic into chronic migraine and may increase migraine-related disability.Thus, given the multifactorial origin of the condition, the application of a biopsychosocial approach in the management of migraine could favor therapeutic success. While in chronic pain conditions the biopsychosocial approach is already a mainstay of treatment, in migraine the biomedical approach is still dominant. It is instead advisable to carefully consider the individual with migraine as a whole, in order to plan a tailored treatment. In this review, we first reported an analytical and critical discussion of the biological, psychological, and social factors involved in migraine. Then, we addressed the management implications of the application of a biopsychosocial model discussing how the integration between non-pharmacological management and conventional biomedical treatment may provide advantages to migraine care.© 2022. The Author(s).

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