• Yael Levy, Alice Hutin, Nicolas Polge, Fanny Lidouren, Rocio Fernandez, Matthias Kohlhauer, Pierre-Louis Leger, Jérôme Rambaud, Guillaume Debaty, Keith Lurie, Bijan Ghaleh, Lionel Lamhaut, and Renaud Tissier.
• CNRS TIMC Laboratory - UMR 5525, Department of Emergency Medicine, Grenoble Alpes University Hospital, Université Grenoble Alpes, Grenoble, France.
• Shock. 2022 Sep 1; 58 (3): 236240236-240.

AbstractAim: Head and thorax elevation during cardiopulmonary resuscitation improves cerebral hemodynamics and ultimate neurological outcome after cardiac arrest. Its effect during extracorporeal cardiopulmonary resuscitation (E-CPR) is unknown. We tested whether this procedure could improve hemodynamics in swine treated by E-CPR. Methods and Results: Pigs were anesthetized and submitted to 15 minutes of untreated ventricular fibrillation followed by E-CPR. Animals randomly remained in flat position (flat group) or underwent head and thorax elevation since E-CPR institution (head-up group). Electric shocks were delivered after 30 minutes until the return of spontaneous circulation (ROSC). They were followed during 120 minutes after ROSC. After 30 minutes of E-CPR, ROSC was achieved in all animals, with no difference regarding blood pressure, heart rate, and extracorporeal membrane of oxygenation flow among groups. The head-up group had an attenuated increase in ICP as compared with the flat group after cardiac arrest (13 ± 1 vs. 26 ± 2 mm Hg at the end of the follow-up, respectively). Cerebral perfusion pressure tended to be higher in the head-up versus flat group despite not achieving statistical difference (66 ± 1 vs 46 ± 1 mm Hg at the end of the follow-up). Carotid blood flow and cerebral oxygen saturation were not significantly different among groups. Conclusion: During E-CPR, head and thorax elevation prevents ICP increase. Whether it could improve the ultimate neurological outcome in this situation deserves further investigation.Copyright © 2022 by the Shock Society.

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