• Shock · Sep 2022

    Review

    Goodnight, sleep tight, don't let the microbes bite: a review of sleep and its effects on sepsis and inflammation.

    • Wendy E Walker.
    • Center of Emphasis in Infectious Diseases, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, and Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El Paso, El Paso, TX.
    • Shock. 2022 Sep 1; 58 (3): 189195189-195.

    AbstractSleep is a restorative biological process that is crucial for health and homeostasis. However, patient sleep is frequently interrupted in the hospital environment, particularly within the intensive care unit. Suboptimal sleep may alter the immune response and make patients more vulnerable to infection and sepsis. In addition, hospitalized patients with sepsis experience altered sleep relative to patients without infectious disease, suggesting a bidirectional interplay. Preclinical studies have generated complementary findings, and together, these studies have expanded our mechanistic understanding. This review article summarizes clinical and preclinical studies describing how sleep affects inflammation and the host's susceptibility to infection. We also highlight potential strategies to reverse the detrimental effects of sleep interruption in the intensive care unit.Copyright © 2022 by the Shock Society.

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