• Yunlong Ding, Yan Liu, Qing Huang, Li Ma, Youyong Tian, Junshan Zhou, and Jiali Niu.
• Department of Neurology, Jingjiang People's Hospital, Seventh Affiliated Hospital of Yangzhou University, Jiangsu.
• J Emerg Med. 2022 Aug 1; 63 (2): 232239232-239.

BackgroundChronic kidney disease (CKD) is associated with a higher mortality rate and a poor prognosis among patients with acute ischemic stroke (AIS) who receive intravenous thrombolysis (IVT); however, it is still unclear whether IVT improves the prognosis of patients with AIS and CKD.ObjectiveWe conducted this study to evaluate the impact of IVT in patients with AIS and CKD.MethodsWe analyzed patients with AIS and CKD in 3 stroke centers who met the indications for IVT between January 2015 and January 2020. The patients were grouped into an IVT group and a non-IVT group according to whether patients received IVT. After propensity score matching at a 1:1 ratio, symptomatic intracranial hemorrhage (sICH) and the modified Rankin Scale (mRS) score at 3 months were compared to assess the safety and efficacy of IVT in patients with AIS with CKD.ResultsA total of 888 patients were enrolled: 763 in the IVT group and 125 in the non-IVT group. After matching, 250 patients were analyzed, and no significant differences were found in sICH between the 2 groups. However, the IVT group had a better 90-day mRS (0-2) score (70.4% vs. 57.6; p = 0.048) than the non-IVT group.ConclusionsIVT improved the 3-month prognosis and did not increase the occurrence of sICH among patients with AIS with CKD.Copyright © 2022 Elsevier Inc. All rights reserved.

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