• Am J Emerg Med · Nov 2022

    Case Reports

    Acute pulmonary emboli following rebound phenomenon after Nirmatrelvir/Ritonavir treatment for COVID-19.

    • Morgan Birabaharan and Thomas C S Martin.
    • Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, La Jolla, CA, USA. Electronic address: mbirabaharan39@gmail.com.
    • Am J Emerg Med. 2022 Nov 1; 61: 235.e5235.e6235.e5-235.e6.

    AbstractThe return of COVID-19 symptoms after Nirmatrelvir/Ritonavir (Nm/R) treatment is being increasingly reported. Limited evidence suggests most cases of rebound symptoms are mild and do not require further intervention. Here we present a male veteran reporting rebound symptoms who was found to be hypoxic with pulmonary emboli. Our case highlights the need to evaluate known complications of SARS-CoV-2 including venous thromboembolism in patients reporting recurring symptoms. Further, cases of severe rebound phenomenon should continue to be reported by clinicians to better appreciate the use of the Nm/R during the Omicron wave and among vaccinated persons.Copyright © 2022 Elsevier Inc. All rights reserved.

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