• Internal medicine · Jan 2022

    Case Reports

    Hypercalcemia Associated with the Ectopic Expression of 25-hydroxyvitamin D3-1α-hydroxylase in Diffuse Large B-cell Lymphoma.

    • Masashi Ogawa, Maho Morikawa, Masaki Kobatake, Taku Murakami, Yuki Yamamoto, Rikiya Watanabe, Katsumi Yamada, Katsuhito Nishiyama, Yoshiro Yasutomo, and Kenta Hara.
    • Department of Diabetes and Endocrine Disease, Kita-Harima Medical Center, Japan.
    • Intern. Med. 2022 Jan 1; 61 (16): 248924952489-2495.

    AbstractAn 82-year-old man was transferred to our hospital due to impaired consciousness. His albumin-corrected calcium level was 14.2 mg/dL, intact parathyroid hormone (PTH) and PTH-related protein levels were reduced, and his 1,25-dihydroxyvitamin D [1,25 (OH) 2VitD] level was elevated at 71.5 pg/mL. Computed tomography revealed masses on the bilateral ribs. The mass on the rib was biopsied and diagnosed as diffuse large B-cell lymphoma (DLBCL). Immunostaining of the biopsy sample with the anti-CYP27B1 antibody revealed the ectopic expression of 1α-hydroxylase in the lesion. We herein report a rare case of hypercalcemia induced by the overproduction of 1,25 (OH) 2VitD in DLBCL ectopically expressing 1α-hydroxylase.

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