• Afshin Borhani-Haghighi, Etrat Hooshmandi, Farzaneh Zahediasl, Hossein Molavi Vardanjani, Mahdiyeh Rezaei, Abbas Rahimi-Jaberi, Nahid Ashjazadeh, Peyman Petramfar, Vahid Reza Ostovan, Nima Fadakar, Maryam Poursadeghfard, Sadegh Izadi, Masoumeh Nazeri, Seyedeh Shaghayegh Zafarmand, Mahnaz Bayat, Mohammad Saied Salehi, Maryam Owjfard, Behnaz Sedighi, Farhad Iranmanesh, Kaveh Shafiei, Alireza Vakilian, Amir Moghadam Ahmadi, Reza Nemati, Fatemeh Rezaeian Jahromi, Maryam Jalalijahromi, Kaveh Kashani, Saeed Razmeh, Mansour Bahrehbar, Marzieh Basir, and Adnan I Qureshi.
• Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
• J Neuroimaging. 2022 Nov 1; 32 (6): 116111691161-1169.

Background And PurposeCarotid angioplasty and stenting (CAS) could be considered for preventing stroke in patients with carotid artery stenosis. This study aimed to determine the incidence and the risk factors of the early and mid-term complications associated with CAS.MethodsThis is a retrospective cohort study conducted at Shiraz University of Medical Sciences from March 2011 to March 2019. Patients at high risk and standard risk for carotid endarterectomy were included. The primary composite outcome was defined as stroke, myocardial infarction (MI), and death in the first 30 days after CAS. All-cause mortality, vascular mortality, and stroke were investigated during mid-term follow-up.ResultsA total of 579 patients (618 CAS) were recruited (mean age: 71.52 years). Overall, 394 (68.40%), 211 (36.63%), 179 (31.07%), and 96 (16.72%) patients had hypertension, dyslipidemia, diabetes mellitus, or were cigarette smokers, respectively. Primary composite outcomes were observed in 2.59% of patients (1.55% stroke, 0.69% MI, and 1.72% death). Atrial fibrillation was a predictor of primary composite outcome in multivariate logistic regression (p = .048). The presence of total occlusion in the contralateral carotid artery was significantly associated with the risk of stroke in univariate logistic regression (p = .041). The patients were followed for a period ranging from 1 to 83 months. The overall survival rate for all-cause mortality was 93.48% at 1 year, 77.24% at 5 years, and 52.92% at 8 years. All-cause mortality was significantly higher among patients with symptomatic carotid stenosis (p = .014).ConclusionCAS provides acceptable short-term and mid-term outcomes in a unique population of high- and standard-surgical-risk, symptomatic and asymptomatic, octogenarian, and nonoctogenarian patients.© 2022 American Society of Neuroimaging.

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