• Xuehua Xiong, Mingchao Fan, Junwei Ma, and Jianping Deng.
• Chongqing Emergency Medical Center, Chongqing University Central Hospital, School of Medicine, Chongqing University, Chongqing, China.
• World Neurosurg. 2022 Nov 1; 167: e378e385e378-e385.

BackgroundSeveral studies have shown atrial fibrillation (AF) and cardioembolic stroke (CES) to be associated with the risk of poststroke delirium (PSD). However, other studies have reported inconsistent results. We performed a comprehensive meta-analysis to clarify the associations between AF and CES and PSD susceptibility.MethodsWe searched relevant studies meeting inclusion criteria in PubMed, Google Scholar, and Web of Science. Useful data were pooled, and odds ratios and 95% confidence intervals were calculated. We also assessed heterogeneity among studies, performed sensitivity analyses, and estimated publication bias.ResultsThis meta-analysis containing 18 observational studies proved that AF (odds ratio =2.30, 95% confidence interval = 2.00-2.65, P < 0.0001) was associated with an increased risk of PSD. CES was also found to have a higher risk of delirium compared with other types of stroke based on the Trial of Org 10172 in Acute Stroke Treatment classification (odds ratio = 2.02, 95% confidence interval = 1.47-2.79, P < 0.0001).ConclusionsOur meta-analysis suggested that AF and CES contribute to increased risk of PSD.Copyright © 2022 Elsevier Inc. All rights reserved.

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