• Hui Feng, Yinliang Qi, Xinlong Wang, Fangyu Chen, and Xueping Li.
• Department of Rehabilitation, The Affiliated Jiangning Hospital of Nanjing Medical University, No. 169 Hushan Road, Dongshan Street, Jiangning District, Nanjing, 210000, Jiangsu, China. fenghui007@njmu.edu.cn.
• Neurocrit Care. 2023 Apr 1; 38 (2): 279287279-287.

BackgroundLong-term bed rest in neurointensive care (NIC) patients leads to skeletal muscle atrophy and cognitive dysfunction, which seriously affects the physical fitness and final prognosis of critically ill patients. Exercise therapy plays an increasingly important role in the treatment and rehabilitation of patients with sarcopenia. However, the therapeutic effect and mechanism of exercise therapy for patients with neurological impairment remain unclear.MethodsSerum samples of NIC patients before and after exercise therapy and normal people were collected to detect interleukin-6 (IL-6) and interleukin-1β levels by enzyme-linked immunosorbent assay (ELISA). Middle cerebral artery occlusion (MCAO) was used for the construction of a rat model. The Morris water maze test, exploration test, and open-field test were used to assess neurological function in rats. Western blot and quantitative real-time polymerase chain reaction were performed to evaluate the activation of IL-6/adenosine-monophosphate-activated protein kinase (AMPK) signaling.ResultsExercise therapy attenuated IL-6 expression in NIC patients. Exercise therapy alleviated cognitive dysfunctions and decreased IL-6 expression in MCAO rats. Exercise therapy alleviated gastrocnemius muscle injury in rats after MCAO by modulating IL-6/AMPK signaling.ConclusionsTreadmill exercise decreases inflammation in MCAO rats via modulating IL-6/AMPK signaling.© 2022. Springer Science+Business Media, LLC, part of Springer Nature and Neurocritical Care Society.

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