• HofhuisJosé G MJGM0000-0001-6929-8317Department of Intensive Care, Gelre Hospitals, Albert Schweitzerlaan 31, 7334 DZ, Apeldoorn, The Netherlands. j.hofhuis@gelre.nl.Expertise Center for Intensive Care Rehabilitation Apeldoorn (ExpIRA), Albert Schweitzerl, Tjard Schermer, and Peter E Spronk.
• Department of Intensive Care, Gelre Hospitals, Albert Schweitzerlaan 31, 7334 DZ, Apeldoorn, The Netherlands. j.hofhuis@gelre.nl.
• Intensive Care Med. 2022 Sep 1; 48 (9): 119712051197-1205.

PurposeDelirium during intensive care unit (ICU) stay may be related to premorbid mental illness. In addition, delirium during ICU stay may also negatively affect long-term health-related quality of life. The aim of our study was to investigate if delirium in the ICU is related to premorbid mental quality of life and affects long-term mental quality of life after ICU stay.MethodsWe performed a prospective cohort study in 1021 patients admitted for longer than 48 h in a medical-surgical ICU. We evaluated mental and physical quality of life using the Short-form-12 before ICU admission, at hospital discharge, and 3, 6 and 12 months after hospital discharge. Mixed model and logistic regression models were used to analyze the data.ResultsPatients who experienced a delirium during ICU stay reported a worse pre-admission mental quality of life than those without delirium (p < 0.001). Furthermore, patients who suffered from delirium during their ICU stay exhibited a significant decrease in mental quality of life over time relative to patients without delirium (p = 0.035).ConclusionIn this large follow-up study, we demonstrated that ICU survivors who experienced a delirium during ICU stay reported a significantly worse pre-admission mental health-related quality of life and a significant decrease in mental health-related quality of life in the year after hospital discharge compared with patients without delirium.© 2022. Springer-Verlag GmbH Germany, part of Springer Nature.

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