• Hallbera Gudmundsdottir, Daniel S Ubl, Kathleen J Yost, Halena M Gazelka, Elizabeth B Habermann, and Cornelius A Thiels.
• Department of Surgery, Mayo Clinic, Rochester, MN.
• Ann. Surg. 2023 Aug 1; 278 (2): 208215208-215.

ObjectiveTo compare patient-reported outcomes before and after implementation of evidence-based, procedure-specific opioid prescribing guidelines.BackgroundThe opioid epidemic remains a significant public health issue. Many institutions have responded by reducing opioid prescribing after surgery. However, the impact of this on patient-reported outcomes remains poorly understood.MethodsOpioid-naïve adults undergoing 12 elective general surgery procedures at a single institution prospectively completed telephone surveys at median 26 days from discharge. Patients were compared before (March 2017-January 2018) and after (May 2019-November 2019) implementation of evidence-based, procedure-specific opioid prescribing guidelines.ResultsA total of 603 preguideline and 138 postguideline patients met inclusion criteria and completed surveys. Overall, 60.5% of preguideline and 92.5% of postguideline prescriptions fell within recommendations ( P <0.001), while refill rates were similar (4.5% vs 5.8%, P =0.50). A statistically significant drop in median morphine milligram equivalent prescribed was observed for 9 of 12 procedures (75%). No opioids were prescribed for 16.7% of patients in both cohorts ( P =0.98). While 93.3% of preguideline and 87.7% of postguideline patients were very/somewhat satisfied with their pain control, the proportion of patients who were very/somewhat dissatisfied increased from 4.2% to 9.4% ( P =0.039).ConclusionsPrescribing guidelines successfully reduced opioid prescribing without increased refill rates. Despite decreased prescribing overall, there was a continued reluctance to prescribe no opioids after surgery. Although most patients experienced good pain control, there remains a subset of patients whose pain is not optimally managed in the era of reduced opioid prescribing.Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.

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