• Internal medicine · Apr 2023

    Case Reports

    Glycemic Excursion and Insulin Action Revealed in a Rare Case of Type 1 Diabetes Complicated with Short Bowel Syndrome.

    • Yoshihisa Hiromine, Shinsuke Noso, Naru Babaya, Yasunori Taketomo, Fumimaru Niwano, Yuki Okuda, Sara Yasutake, Tatsuro Minohara, Naonobu Tsuda, Yuichiro Hama, and Hiroshi Ikegami.
    • Department of Endocrinology, Metabolism and Diabetes, Kindai University Faculty of Medicine, Japan.
    • Intern. Med. 2023 Apr 1; 62 (7): 102310291023-1029.

    AbstractWe herein report a 52-year-old woman with a rare combination of short bowel syndrome due to massive resection of the small intestine and complete loss of endogenous insulin due to type 1 diabetes. To provide nutritional support, she was treated with total parenteral nutrition with co-administration of insulin, requiring careful matching of insulin and glucose levels. This case report provides insights on glycemic excursion and insulin action in type 1 diabetes, even when both insulin and glucose are administered directly into circulation, and the usual obstacles caused by subcutaneous injection of insulin and oral intake of nutrients are eliminated.

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