• Alexandra Iulia Stoica, Marius Mihai Harpa, Cosmin Marian Banceu, Claudiu Ghiragosian, Carmen Elena Opris, Hussam Al-Hussein, Hamida Al-Hussein, Sanziana Flamind Oltean, Tibor Mezei, Razvan Gheorghita Mares, and Horatiu Suciu.
• Emergency Institute for Cardiovascular Diseases and Transplantation Targu Mures, 540136 Mures, Romania.
• Medicina (Kaunas). 2022 Jul 28; 58 (8).

AbstractCardiac undifferentiated pleomorphic sarcoma (UPS) associated with fever and inflammatory response is an extremely rare condition. Herein, we report a rare case of cardiac UPS with unusual clinical presentation and inflammatory response. A 67-year-old male complaining of progressive dyspnea and intermittent fever of unknown cause was referred to our hospital for surgical resection of a left atrial mass. Laboratory analysis showed leukocytosis (26 × 103/μL) and high C-reactive protein (CRP) levels (155.4 mg/L). Hemoculture tests and urine analysis were negative for infection. A contrast chest computed tomography revealed a mass measuring 5.5 × 4.5 cm, occupying the left atrium cavity. The patient underwent surgical excision of the mass, however, surgical margin of the resected tumor could not be evaluated, due to the multifragmented nature of the resection specimen. Postoperative CRP and leukocyte levels normalized, highlighting the relationship between the tumor and the inflammatory status. Early diagnosis is crucial for a proper management and favorable outcome, enabling patients to undergo chemotherapy and achieve complete surgical resection.

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