• Am J Emerg Med · Nov 2022

    Review

    Toxicity of abortifacients: A review for physicians in the post roe era.

    • Maryann Mazer-Amirshahi and Peggy Ye.
    • Department of Emergency Medicine, MedStar Washington Hospital Center, Washington, DC, United States of America; Georgetown University School of Medicine, Washington, DC, United States of America. Electronic address: maryannmazer@gmail.com.
    • Am J Emerg Med. 2022 Nov 1; 61: 7117-11.

    BackgroundOn June 24, 2022, the Supreme Court overturned Roe v. Wade, which will limit legal abortion in many areas of the U.S. Over half of abortions in the U.S. are performed using medication as opposed to surgical techniques. With widespread access to agents that are used for medication abortion, there may be an increase in emergency department presentations related to improper or unsupervised use of these medications.MethodsThis narrative review focuses on the contraindications, adverse effects, and toxicities of the most common agents used for medication abortion in the U.S.ResultsMedications included in this review are mifepristone, misoprostol, and methotrexate. Each of these medications has a unique adverse effect and toxicity profile.ConclusionAgents used for medication abortion have unique contraindications and adverse effects. Improper or unsupervised use may occur in the setting of limited abortion access and emergency medicine physicians are on the front lines in managing these presentations.Copyright © 2022 Elsevier Inc. All rights reserved.

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