• Ke-Wu Wang, Yang-Miao Xu, Chao-Bin Lou, Jing Huang, and Chao Feng.
• The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, China.
• Clinics (Sao Paulo). 2022 Jan 1; 77: 100095.

ObjectivesDepression is common after both lacunar stroke and non-lacunar stroke and might be associated with lesion locations as proven by some studies. This study aimed to identify whether lesion location was critical for depression after both lacunar and non-lacunar strokes.MethodsA cohort of ischemic stroke patients was assigned to either a lacunar stroke group or a non-lacunar stroke group after a brain MRI scan. Neurological deficits and treatment response was evaluated during hospitalization. The occurrence of depression was evaluated 3 months later. Logistic regressions were used to identify the independent risk factors for depression after lacunar and non-lacunar stroke respectively.Results83 of 246 patients with lacunar stroke and 71 of 185 patients with non-lacunar stroke developed depression. Infarctions in the frontal cortex, severe neurological deficits, and a high degree of handicap were identified as the independent risk factors for depression after non-lacunar stroke, while lesion location was not associated with depression after lacunar stroke.ConclusionThe main determinants for depression after lacunar and non-lacunar stroke were different. Lesion location was critical only for depression after non-lacunar stroke.Copyright © 2022 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.

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