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- Serena MacMillan, Sarah A Hosgood, and Michael L Nicholson.
- Department of Surgery, University of Cambridge, Cambridge, UK.
- Br J Surg. 2023 Jan 10; 110 (2): 133137133-137.
AbstractA major restriction to transplantation is the requirement for ABO blood group compatibility between donor and recipient. In this study, an α-galactosidase enzyme from Bacteroides fragilis was used successfully to remove type B blood group antigens enzymatically from human kidneys using ex vivo normothermic machine perfusion. This provides the first step for a strategy to overcome the ABO barrier in kidney transplantation.
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