• Internal medicine · Apr 2023

    Case Reports

    A Case of Copper Deficiency in Wilson's Disease with a Normal Zinc Value.

    • Masayuki Ueda, Kazuto Katsuse, Toshiyuki Kakumoto, Satoshi Kobayashi, Hiroyuki Ishiura, Jun Mitsui, and Tatsushi Toda.
    • Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan.
    • Intern. Med. 2023 Apr 1; 62 (7): 107310761073-1076.

    AbstractCopper deficiency (CD) is a rare complication of long-term treatment of Wilson's disease (WD) and is usually accompanied by high serum zinc levels. A 57-year-old woman with WD presented with limb weakness and sensory disturbance due to myeloneuropathy and macrocytic anemia after 36 years of treatment. Markedly reduced serum free copper values confirmed CD, which was considered to be caused by progressive dysphagia and severe diarrhea rather than zinc overdose because of the normal serum zinc levels. Discontinuing copper-reducing therapy and increasing copper intake improved her symptoms. Physicians should be alert for the risk of CD in WD patients, especially those with dysphagia.

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