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- Risako Kohya, Ryo Sugiura, Yoshiya Yamamoto, Hirohito Naruse, Kazuteru Hatanaka, Kenji Kinoshita, Satoshi Abiko, Shuichi Miyamoto, Kazuharu Suzuki, Hanae Kushibiki, Satoru Munakata, and Norihiko Shimoyama.
- Department of Gastroenterology and Hepatology, Hakodate Municipal Hospital, Japan.
- Intern. Med. 2023 Apr 1; 62 (7): 995998995-998.
AbstractHepatocellular carcinoma (HCC) hemorrhaging/rupture is a rare adverse effect of lenvatinib, and only limited pathological examinations have been reported. This report presents the case of a 69-year-old man who suffered from cardiac arrest and died 7 days after starting lenvatinib treatment for HCC, with an autopsy subsequently performed. Crack and coagulated blood were observed in the largest tumor. Pathologically, the hemorrhaging area was scattered in nearly all of the HCC lesions, regardless of tumor differentiation. This pathological feature is unusual in normal HCC. Thus, it is believed to have been the effect of lenvatinib.
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