• Katja M Gist, Dana Fuhrman, Natalja Stanski, Shina Menon, and Danielle E Soranno.
• Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.
• Curr Opin Crit Care. 2022 Dec 1; 28 (6): 590598590-598.

Purpose Of ReviewThe purpose of this review is to describe acute kidney injury (AKI) phenotypes in children.Recent FindingsAKI is a heterogenous disease that imposes significant morbidity and mortality on critically ill and noncritically ill patients across the age spectrum. As our understanding of AKI and its association with outcomes has improved, it is becoming increasingly apparent that there are distinct AKI subphenotypes that vary by cause or associated conditions. We have also learned that severity, duration, and repeated episodes of AKI impact outcomes, and that integration of novel urinary biomarkers of tubular injury can also reveal unique subphenotypes of AKI that may not be otherwise readily apparent.SummaryStudies that further delineate these unique AKI subphenotypes are needed to better understand the impact of AKI in children. Further delineation of these phenotypes has both prognostic and therapeutic implications.Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.

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