• Martina Bocchetta, Marina Boccardi, Rossana Ganzola, Liana G Apostolova, Gregory Preboske, Dominik Wolf, Clarissa Ferrari, Patrizio Pasqualetti, Nicolas Robitaille, Simon Duchesne, Clifford R Jack, Giovanni B Frisoni, and EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Segmentation and for the Alzheimer's Disease Neuroimaging Initiative.
• LENITEM (Laboratory of Epidemiology, Neuroimaging and Telemedicine), IRCCS-Centro S. Giovanni di Dio-Fatebenefratelli Brescia, Brescia, Italy; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
• Alzheimers Dement. 2015 Feb 1; 11 (2): 151-60.e5.

BackgroundA globally harmonized protocol (HarP) for manual hippocampal segmentation based on magnetic resonance has been recently developed by a task force from European Alzheimer's Disease Consortium (EADC) and Alzheimer's Disease Neuroimaging Initiative (ADNI). Our aim was to produce benchmark labels based on the HarP for manual segmentation.MethodsFive experts of manual hippocampal segmentation underwent specific training on the HarP and segmented 40 right and left hippocampi from 10 ADNI subjects on both 1.5 T and 3 T scans. An independent expert visually checked segmentations for compliance with the HarP. Descriptive measures of agreement between tracers were intraclass correlation coefficients (ICCs) of crude volumes and similarity coefficients of three-dimensional volumes.ResultsTwo hundred labels have been provided for the 20 magnetic resonance images. Intra- and interrater ICCs were >0.94, and mean similarity coefficients were 1.5 T, 0.73 (95% confidence interval [CI], 0.71-0.75); 3 T, 0.75 (95% CI, 0.74-0.76).ConclusionCertified benchmark labels have been produced based on the HarP to be used for tracers' training and qualification.Copyright © 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

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