• Davis C Thomas, Prisly Thomas, Deep P Pillai, Dahlia Joseph, Upasana Lingaiah, Blessy C Mathai, Anjali Ravi, Surabhi Chhabra, and Priyanka Kodaganallur Pitchumani.
• Center for TMD and Orofacial Pain, Rutgers School of Dental Medicine, Newark, NJ, USA. davisct1@gmail.com.
• Curr Pain Headache Rep. 2022 Oct 1; 26 (10): 725-740.

Purpose Of ReviewGiant cell arteritis (GCA) is a chronic, inflammatory condition, primarily affecting the medium and larger arteries. The purpose of this narrative review is to describe GCA in the context of headache and facial pain, based on a case and the available current literature. Understanding the etiology, pathophysiology, the associated conditions, and the differential diagnoses is important in managing GCA.Recent FindingsIn a patient presenting with unilateral facial/head pain with disturbances of vision, GCA should be considered in the differential diagnosis. There is an association of GCA with several comorbid conditions, and infections including coronavirus-19 (COVID-19) infection. Management of GCA primarily depends upon the identification of the affected artery and prompt treatment. Permanent visual loss and other serious complications are associated with GCA. GCA is characterized by robust inflammation of large- and medium-sized arteries and marked elevation of systemic mediators of inflammation. An interdisciplinary approach of management involving the pertinent specialties is strongly recommended.© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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