• Internal medicine · Apr 2023

    Case Reports

    The Postpartum Period Can Worsen Myelin Oligodendrocyte Glycoprotein Antibody-associated Encephalomyelitis: A Case Report.

    • Shizuka Yamamoto, Mitsutake Yano, Yuko Miyamoto, Takuya Hanaoka, Yoshihiro Nishida, and Yasushi Kawano.
    • Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Japan.
    • Intern. Med. 2023 Apr 1; 62 (7): 106310661063-1066.

    AbstractMyelin oligodendrocyte glycoprotein (MOG) antibodies are associated with relapsing inflammatory demyelinating disease. Pregnancy complicates the disease course, potentially leading to either symptom improvement or worsening. A 28-year-old woman with MOG antibody-associated encephalomyelitis had 2 pregnancies; her disease worsened during both postpartum periods despite continuing prednisolone and levetiracetam. The umbilical cord blood was positive for MOG antibodies following her second pregnancy, but neither baby had MOG antibody-associated disease. This is the first case report of MOG antibody-associated demyelinating disease that worsened postpartum despite continuous medication. Furthermore, we observed the placental transfer of MOG antibodies for the first time.

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