• Internal medicine · Apr 2023

    Case Reports

    Crescentic Glomerulonephritis with Fibrinoid Vasculitis after Administration of Influenza Vaccine: A Case Report.

    • Risa Hara, Eiko Hasegawa, Noriko Inoue, Akinari Sekine, Kiho Tanaka, Daisuke Ikuma, Hiroki Mizuno, Yuki Oba, Masayuki Yamanouchi, Tatsuya Suwabe, Naoki Sawa, Kei Kono, Keiichi Kinowaki, Kenichi Ohashi, Yoshifumi Ubara, and Junichi Hoshino.
    • Nephrology Center, Toranomon Hospital, Japan.
    • Intern. Med. 2023 Apr 1; 62 (7): 107710801077-1080.

    AbstractA 66-year-old man was admitted to our hospital because of a low-grade fever and arthralgia. The symptoms started on the third day after influenza vaccine administration and persisted for two months. Serum creatinine was 1.0 mg/dL; C-reactive protein, 16.1 mg/dL; and myeloperoxidase antineutrophil cytoplasmic antibodies (MPO-ANCA), 4,170 IU/mL. A kidney biopsy showed crescentic glomerulonephritis with fibrinoid necrosis of small arteries. Microscopic polyangiitis was diagnosed. After five months of steroid pulse therapy and rituximab administration, the patient entered remission. There have been very few reports of this condition after influenza vaccine administration.

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