• Internal medicine · Apr 2023

    Case Reports

    A Case of Anti-MDA-5 Antibody-positive Dermatomyositis after Allogeneic Bone Marrow Transplantation for Acute Transformation of Chronic Myelogenous Leukemia.

    • Mariko Futamura, Yoshio Ozaki, Hidehiko Makino, Saki Tsujimoto, Minoru Shigesaka, Akihiro Tanaka, Keiko Shimamoto, Yonsu Son, Tomoki Ito, and Shosaku Nomura.
    • Department of Rheumatology and Clinical Immunology, Kansai Medical University Hospital, Japan.
    • Intern. Med. 2023 Apr 1; 62 (7): 108110871081-1087.

    AbstractAnti-melanoma differentiation-associated gene 5 (MDA-5) antibody-positive dermatomyositis is a disease with a poor prognosis associated with rapid progressive interstitial pneumonia. Autoimmune diseases have occasionally been reported to occur after hematopoietic stem cell transplantation (HSCT). We experienced a case of anti-MDA-5 antibody-positive dermatomyositis after HSCT. In this case, a sufficient dose of cyclophosphamide could not be administered due to an impaired bone marrow function. We discuss the complications of autoimmune diseases after HSCT.

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