• Neurosurgery · Oct 2022

    Interictal Connectivity Revealed by Granger Analysis of Stereoelectroencephalography: Association With Ictal Onset Zone, Resection, and Outcome.

    • StoneScellig S DSSDEpilepsy Surgery Program, Department of Neurosurgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Eun-Hyoung Park, Jeffrey Bolton, Chellamani Harini, Mark H Libenson, Alexander Rotenberg, Masanori Takeoka, Melissa Tsuboyama, Phillip L Pearl, and Joseph R Madsen.
    • Epilepsy Surgery Program, Department of Neurosurgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
    • Neurosurgery. 2022 Oct 1; 91 (4): 583589583-589.

    BackgroundStereoelectroencephalography (sEEG) facilitates electrical sampling and evaluation of complex deep-seated, dispersed, and multifocal locations. Granger causality (GC), previously used to study seizure networks using interictal data from subdural grids, may help identify the seizure-onset zone from interictal sEEG recordings.ObjectiveTo examine whether statistical analysis of interictal sEEG helps identify surgical target sites and whether surgical resection of highly ranked nodes correspond to favorable outcomes.MethodsTen minutes of extraoperative recordings from sequential patients who underwent sEEG evaluation were analyzed (n = 20). GC maps were compared with clinically defined surgical targets using rank order statistics. Outcomes of patients with focal resection/ablation with median follow-up of 3.6 years were classified as favorable (Engel 1, 2) or poor (Engel 3, 4) to assess their relationship with the removal of highly ranked nodes using the Wilcoxon rank-sum test.ResultsIn 12 of 20 cases, the rankings of contacts (based on the sum of outward connection weights) mapped to the seizure-onset zone showed higher causal node connectivity than predicted by chance ( P ≤ .02). A very low aggregate probability ( P < 10 -18 , n = 20) suggests that causal node connectivity predicts seizure networks. In 8 of 16 with outcome data, causal connectivity in the resection was significantly greater than in the remaining contacts ( P ≤ .05). We found a significant association between favorable outcome and the presence of highly ranked nodes in the resection ( P < .05).ConclusionGranger analysis can identify seizure foci from interictal sEEG and correlates highly ranked nodes with favorable outcome, potentially informing surgical decision-making without reliance on ictal recordings.Copyright © Congress of Neurological Surgeons 2022. All rights reserved.

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