• Hye Ran Park, Hyung-Jun Im, Jeongbin Park, Byung Woo Yoon, Yong Hoon Lim, Eun Jin Song, Kyung Ran Kim, Jae Meen Lee, Kawngwoo Park, Kwang Hyon Park, Hyun Joo Park, Jung-Hwan Shin, Kyung Ah Woo, Jee Young Lee, Suyeon Park, Han-Joon Kim, Beomseok Jeon, and Sun Ha Paek.
• Department of Neurosurgery, Soonchunhyang University Seoul Hospital, Seoul, Korea.
• Neurosurgery. 2022 Nov 1; 91 (5): 726733726-733.

BackgroundDeep brain stimulation (DBS) of the subthalamic nucleus (STN) represents an effective treatment for severe Parkinson's disease (PD), but little is known about the long-term benefit.ObjectiveTo investigate the survival rate and long-term outcome of DBS.MethodsWe investigated all 81 patients including 37 males and 44 females who underwent bilateral STN DBS from March 2005 to March 2008 at a single institution. The current survival status of the patients was investigated. Preoperative and postoperative follow-up assessments were analyzed.ResultsThe mean age at the time of surgery was 62 (range 27-82) years, and the median clinical follow-up duration was 145 months. Thirty-five patients (43%) died during the follow-up period. The mean duration from DBS surgery to death was 110.46 ± 40.8 (range 0-155) months. The cumulative survival rate is as follows: 98.8 ± 1.2% (1 year), 95.1 ± 2.4% (5 years), and 79.0 ± 4.5% (10 years). Of the 81 patients, 33 (40%) were ambulatory up to more than 11 years. The Unified Parkinson's Disease Rating Scale (UPDRS) score was significantly improved until 5 years after surgery although it showed a tendency to increase again after 10 years. The patient group with both electrodes located within the STN showed a higher rate of survival and maintained ambulation.ConclusionSTN DBS is a safe and effective treatment for patients with advanced PD. This study based on the long-term follow-up of large patient populations can be used to elucidate the long-term fate of patients who underwent bilateral STN DBS for PD.Copyright © Congress of Neurological Surgeons 2022. All rights reserved.

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