• Eric Ochoa-Hein, Patricia E Leal-Morán, Karen A Nava-Guzmán, Abril T Vargas-Fernández, José F Vargas-Fernández, Fabricio Díaz-Rodríguez, Joel Armando Rayas-Bernal, Ricardo González-González, Pavel Vázquez-González, Martha A Huertas-Jiménez, Sandra Rajme-López, Pilar Ramos-Cervantes, Violeta Ibarra-González, Luis A García-Andrade, Fernando Ledesma-Barrientos, Alfredo Ponce-de-León, José Sifuentes-Osornio, and Arturo Galindo-Fraga.
• Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
• Rev Invest Clin. 2022 Jan 1; 74 (4): 175-180.

BackgroundRelatively low SARS-CoV-2 reinfection rates have been reported in vaccinated individuals, but updates considering the Omicron variant are lacking.ObjectivesThe objective of the study was to provide a current estimate of the SARS-CoV-2 reinfection rate in a highly immunized population.MethodsA prospective cohort of Mexican hospital workers was followed (March 2020-February 2022). Reinfection was defined as the occurrence of two or more episodes of COVID-19 separated by a period of ≥ 90 days without symptoms. The reinfection rate was calculated as the number of reinfection episodes per 100,000 persons per day.ResultsA total of 3732 medical consultations were provided to 2700 workers, of whom 1388 (51.4%) were confirmed COVID-19 cases. A total of 73 reinfection cases were identified, of whom 71 (97.3%) had completed their primary vaccination series and 22 (30.1%) had had a booster dose before the second episode. The overall reinfection rate was 23.1 per 100,000 persons per day (as compared to a rate of 1.9 per 100,000 persons per day before the Omicron wave).ConclusionsThe SARS-CoV-2 reinfection rate rose significantly during the Omicron wave despite a high primary vaccination coverage rate. Almost one-third of reinfected workers had a vaccine booster ≥ 14 days before the last COVID-19 episode.Copyright: © 2022 Permanyer.

13 keywords...

hide…