• Karen Malacon, Taiyeb Rangwalla, Harsh Wadhwa, and Corinna Zygourakis.
• School of Medicine, Stanford University Medical Center, Stanford, CA.
• Spine. 2023 Jan 1; 48 (1): 394839-48.

Study DesignRetrospective cohort study.ObjectiveTo assess outcomes and mortality in elderly patients following unstable spine fractures depending on treatment modality.Summary Of Background DataOperative management of unstable spine fractures in the elderly remains controversial due to increased risk of perioperative complications. Mortality rates after operative versus nonoperative treatment of these injuries have not been well-characterized.Materials And MethodsPatients aged above 65 with unstable spine fractures without neurologic injury from 2015 to 2021 were identified from the Clinformatics ® Data Mart (CDM) Database. Demographics, complications, and mortality were collected. Multivariable logistic regression was used to adjust for the effect of baseline characteristics on mortality following unstable fracture diagnosis.ResultsOf the 3688 patients included, 1330 (36.1%) underwent operative management and 2358 (63.9%) nonoperative. At baseline, nonoperative patients were older, female, had higher Elixhauser comorbidity scores, and were more likely to have a cervical fracture. Operative patients had a longer length of stay in the hospital compared with nonoperative patients (9.7 vs. 7.7 days; P <0.001). Although patients in the operative group had higher rates of readmission at 30, 60, 90, and 120 days after diagnosis ( P <0.01), they had lower mortality rates up to five years after injury. After adjusting for covariates, nonoperative patients had a 60% greater risk of mortality compared with operative patients (hazard ratio: 1.60, 95% confidence interval: 1.40-1.78, P <0.001). After propensity score matching, operative patients age 65 to 85 had greater survivorship compared with their nonoperative counterparts.ConclusionsElderly patients with an unstable spine fracture who undergo surgery experience lower mortality rates up to five years postdiagnosis compared with patients who received nonoperative management, despite higher hospital readmission rates and an overall perioperative complication rate of 37.3%. Operating on elderly patients with unstable spine fractures may outweigh the risks and should be considered as a viable treatment option in appropriately selected patients.Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.

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