• Ying Jing, Jinbo Hu, Rong Luo, Yun Mao, Zhixiao Luo, Mingjun Zhang, Jun Yang, Ying Song, Zhengping Feng, Zhihong Wang, Qingfeng Cheng, Linqiang Ma, Yi Yang, Li Zhong, Zhipeng Du, Yue Wang, Ting Luo, Wenwen He, Yue Sun, Fajin Lv, Qifu Li, and Shumin Yang.
• Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China (Y.J., J.H., Y.Song, Z.F., Z.W., Q.C., L.M., Y.Y., Z.D., Y.W., T.L., W.H., Y.Sun, Q.L., S.Y.).
• Ann. Intern. Med. 2022 Oct 1; 175 (10): 1383-1391.

BackgroundWith the widespread use of advanced imaging technology, adrenal tumors are increasingly being identified.ObjectiveTo investigate the prevalence and characteristics of adrenal tumors in an unselected screening population in China.DesignCross-sectional study. (ClinicalTrials.gov: NCT04682938).SettingA health examination center in China.PatientsAdults having an annual checkup were invited to be screened for adrenal tumors by adrenal computed tomography.MeasurementsThe participants with adrenal tumors had further evaluation for malignancy risk and adrenal function.ResultsA total of 25 356 participants were screened, 351 of whom were found to have adrenal tumors, for a prevalence of 1.4%. The prevalence increased with age, from 0.2% in participants aged 18 to 25 years to 3.2% in those older than 65 years. Among 351 participants with adrenal tumors, 337 were diagnosed with an adrenocortical adenoma, 14 with another benign nodule, and none with a malignant mass. In 212 participants with an adenoma who completed endocrine testing, 69.3% were diagnosed with a nonfunctioning adenoma, 18.9% with cortisol autonomy, 11.8% with primary aldosteronism, and none with pheochromocytoma. Proportions of nonfunctioning adenomas were similarly high in various age groups (72.2%, 67.8%, and 72.2% in those aged <46, 46 to 65, and ≥66 years, respectively).LimitationOnly 212 of 337 participants with an adrenocortical adenoma had endocrine testing.ConclusionThe prevalence of adrenal tumors in the general adult screening population is 1.4%, and most of these tumors are nonfunctioning regardless of patient age. Cortisol and aldosterone secretion are the main causes of functional adenomas.Primary Funding SourceNational Key Research and Development Program of China and National Natural Science Foundation of China.

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