• Marta Valero-Expósito, María Martín-López, Carlos Guillén-Astete, Beatriz Joven, Carolina Merino-Argumanez, Valentina Emperiale, Jose Campos, Ana Pérez, and Javier Bachiller-Corral.
• Rheumatology Department, Hospital Universitario Ramón y Cajal and Irycis (Instituto Ramón y Cajal de investigación sanitaria), Madrid, Spain.
• Medicine (Baltimore). 2022 Sep 9; 101 (36): e30444e30444.

AbstractSecukinumab is a novel anti-IL17 biologic treatment approved for the treatment of psoriatic arthritis (PsA). The purpose of the present study is to identify factors that can condition the retention rate of this drug in a real-world scenario. Methods: A multicentric retrospective study was conducted based on the registries of consecutive patients diagnosed with PsA who started secukinumab from January 2016 to December 2018. For purposes of Cox-regression analysis, the time spanning from the first administration of secukinumab until its interruption or the end of the follow-up was considered the independent variable. Variables of known relevance and those who demonstrated direct association with the drug retention rate were included in the model. Results: One hundred seventy-six registries were analyzed (average age at diagnosis 44.7 ± 12.1 years old, 114 females). The median retention rate of secukinumab was 636 days (95% confidence interval [CI] 542.4-729.5). Presence of peripheral arthritis (hazard ratio 0.424 [95% CI 0.213-0.847, P = .015]) and a time of evolution >6 years (hazard ratio 0.468 [95% CI 0.225-0.975, P = .043]) were the 2 variables that showed a significant influence on the drug retention rate. According to our results, patients who exhibit peripheral arthritis and those with a higher evolution time will have more probabilities of a larger secukinumab retention rate.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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