• J Res Med Sci · Jan 2022

    Comparison of proteinase activity, hemolysin production, and adherence ability of Candida albicans isolates obtained from gastroesophageal lesions and urinary tract infections.

    • Forough Rezvani, Mehrnoush Maheronnaghsh, and Rasoul Mohammadi.
    • Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
    • J Res Med Sci. 2022 Jan 1; 27: 58.

    BackgroundAdhesion of Candida to host cell receptors, hemolysin production, and proteinase activity are assumed as principal virulence factors and infection establishment. These virulence factors are essential for colonization, biofilm formation, and attack on the host cells.Materials And MethodsA total of 97 Candida albicans isolates obtained from gastroesophageal lesions and urinary tract infections were included in the study. Adhesion assay, proteinase activity, and hemolysin production were measured. Statistical analysis was performed using the independent t-test and Chi-square test to compare quantitative and qualitative data between the two groups.ResultsThe adherence ability to the buccal epithelial cells was the same in the two groups. Proteinase activity was seen in all clinical isolates. Hemolytic activities were not statistically significant in the two groups.ConclusionOur results recommend that the pathogenicity of C. albicans in the mucous membranes cannot be connected to the infected site.Copyright: © 2022 Journal of Research in Medical Sciences.

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