• Regina Maria Alexandre Fernandes de Oliveira, Milton Luiz Gorzoni, and Ronaldo Fernandes Rosa.
• Undergraduate Medicine Student, School of Medical Sciences, Santa Casa de São Paulo, São Paulo (SP), Brazil.
• Sao Paulo Med J. 2022 Jan 1; 141 (3): e2021914e2021914.

BackgroundThere is discrepant information across countries regarding the natural history of patients admitted to hospitals with coronavirus disease (COVID-19), in addition to a lack of data on the scenario in Brazil.ObjectiveTo determine the mortality predictors in COVID-19 patients admitted to a tertiary hospital in São Paulo, Brazil.Design And SettingA retrospective analysis of medical records of COVID-19 patients admitted to the Hospital Central da Irmandade da Santa Casa de Misericórdia of São Paulo.MethodsOverall, 316 patients with laboratory-confirmed COVID-19 between March 1, 2020, and July 31, 2020, were included. The analysis included the baseline characteristics, clinical progression, and outcomes.ResultsThe mortality rate of the sample was 51.27%. Age ≥ 60 years was determined as a risk factor after multivariate logistic regression analysis. Patients with an oxygen (O2) saturation ≤ 94% upon admission accounted for 87% of the deaths (P < 0.001). Vasoactive drugs were used in 92% (P < 0.001) of patients who progressed to death, and mechanical ventilation was employed in 88% (P < 0.001) of such patients. However, patients who received corticosteroids concomitantly with mechanical ventilation had a better prognosis than those who did not. The progressive degree of pulmonary involvement observed on chest computed tomography was correlated with a worse prognosis. The presence of thrombocytopenia has been considered as a risk factor for mortality.ConclusionThe main predictors of in-hospital mortality after logistic regression analysis were age, O2 saturation ≤ 94% upon admission, use of vasoactive drugs, and presence of thrombocytopenia.

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