• Yuting Zhang, Xiujin Chen, Jiachen Ji, Zhengwei Xu, Honghui Sun, Liang Dong, and Dingjun Hao.
• The Department of Radiology, Hong-Hui Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shannxi, China.
• Pain Physician. 2022 Sep 1; 25 (6): E805-E813.

BackgroundPercutaneous kyphoplasty (PKP) is an effective treatment for osteoporotic vertebral compression fractures (OVCF). Comparisons of different approaches have previously focused primarily on x-rays. Three-dimensional (3D) computed tomography (CT) enables better imaging evaluation of bone cement distribution.ObjectivesTo compare the CT imaging parameters and clinical efficacies of unilateral and bilateral PKP.Study DesignThis was a prospective, nonrandomized controlled study.SettingDepartment of Orthopedics from an affiliated hospital.MethodsSeventy-two single-level OVCF patients who underwent 3D CT between 2018 and 2020 were evaluated prospectively. All patients underwent PKP and were assigned to 2 groups: unilateral PKP and bilateral PKP. Imaging outcomes were assessed by determining the cement volume, leakage, dispersion index, vertebral height (VH) and the cement volume of the noninjected and injected sides. Clinical outcomes were evaluated using the Visual Analog Scale (VAS). The correlations between the bone cement volume or dispersion index and the VAS, VH improvement rate (VHIR), or bone cement leakage were also evaluated.ResultsThe mean follow-up time was 17.1 months. The postoperative VH and VAS in both groups were significantly improved (P < 0.05). However, there were no statistically significant differences in the cement volume, leakage or dispersion index, VH, or VAS between the 2 groups. No statistically significant differences in the cement volume or VH were found between the noninjected and injected sides within the unilateral group. The operative time was significantly shorter in the patients who underwent unilateral PKP. Unilateral PKP in which the bone cement did not cross the midline had a higher VAS compared with bilateral PKP. Both the bone cement volume and dispersion index displayed a positive correlation with the VHIR, but no correlation with the VAS or bone cement leakage.LimitationsThis study was limited by the nonrandomized design, small sample size, and short follow-up period.ConclusionsWhile unilateral PKP was as effective as bilateral PKP, it had a shorter operation time. However, the bilateral PKP approach might be followed when bone cement is distributed in only one side following the unilateral PKP procedure.

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