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Case Reports
Remission of Granulomatosis with Polyangiitis Only After Resection of a Pulmonary Nodule.
- Ryuichiro Kanda, Kazuhisa Nakano, Aya Nawata, Shigeru Iwata, Shingo Nakayamada, and Yoshiya Tanaka.
- The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.
- Intern. Med. 2022 Jan 1; 61 (18): 2803-2808.
AbstractGranulomatosis with polyangiitis (GPA) is characterized by necrotizing granulomatous lesions and is classified as ANCA-associated vasculitis (AAV). We herein report a case of GPA that was remitted by resection of a pulmonary lesion without immunosuppressive therapy. We detected activated neutrophils and neutrophil extracellular traps (NET) formation in resected lung tissue by immunofluorescence. Activated neutrophils and NETs might be involved in the pathophysiology of AAV and induce the vicious cycle of ANCAs and NETs. In cases of GPA with no other severe lesions, the reevaluation of the disease activity after diagnostic resection is crucial for considering the need for immunosuppressive therapy.
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