• Zhi-Biao Gao, Wen-Juan Zhang, Rui Tuo, Xia Xiao, and Wei-Jing Cao.
• Department of Oral and Maxillofacial Surgery, Yanan University Affiliated Hospital, Yan'an, China.
• Medicine (Baltimore). 2022 Sep 2; 101 (35): e30220.

AbstractThis study retrospectively investigated the efficacy of transcranial direct current stimulation (tDCS) in the treatment of anxiety and depression in patients with oral cancer (OC) during the perioperative period (PPP). This retrospective study reviewed the electronic medical records of patients who underwent OC surgery and experienced anxiety and depression during PPP. The patients were divided into the treatment (n = 36) and control (n = 36) groups. The patients in the treatment group received tDCS, whereas those in the control group did not receive tDCS. The primary outcomes included the Self-rating Anxiety Scale (SAS) and the Self-rating Depression Scale (SDS). Secondary outcomes included adverse events (AEs). We analyzed the outcome data before and after treatment. After treatment, patients in the treatment group achieved greater relief in SAS (P < .01) and SDS (P < .01) scores than those in the control group. Regarding safety, no electronic medical records reported any AEs in this study. The results of this study showed that tDCS may help relieve depression and anxiety in patients with OC during PPP. However, high-quality prospective randomized controlled trials are required to confirm these findings.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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