• Junyu Chen, Lianying Ding, Taiwei Wang, Mengqi Wang, Shuhua Zhao, and Yang Xia.
• Departments of Gynecology and Obstetrics, The Second Hospital of Jilin University, Changchun, China.
• Medicine (Baltimore). 2022 Sep 16; 101 (37): e30691.

RationaleDedifferentiated liposarcoma (DL) of the ovary is a rare mesenchymal tumor which is difficult to diagnose before surgery. The diagnose of DL was depended on the morphology, Immunohistochemical stains, and fluorescence in situ hybridization after the complete surgical resection.Patient ConcernsWe report a case of 63-year-old postmenopausal female who presented with a large pelvic mass and was initially thought to be an original ovarian tumor. However, it was subsequently considered to be a DL arising from the mesentery and developing in ovary.DiagnosisOvarian DL.InterventionsBilateral salpingo-oophorectomy.OutcomesUntil now, there is no recurrence symptoms represented in the patient after surgery for 12 months.LessonsDL happening in ovary is rare. In this case, the exact origin of the mass still remains ambiguous because of the lack of morphological evidence. Although retroperitoneum is the most common area of DL origin, we for long suspect that the mass was initially derived from mesentery and developed in ovary. A long-term may help confirm the exact origin of the tumor. Complete surgical resection plays an important role in the treatment.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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