• Xiang Liu, Wei Zeng, Dayang Zheng, Min Tang, and Wangyan Zhou.
• Department of Cardiothoracic Surgery, the Second Affiliated Hospital, University of South China, Hengyang, China.
• Medicine (Baltimore). 2022 Sep 16; 101 (37): e30440.

BackgroundNumerous studies have investigated the clinical significance of securin expression in solid cancers; however, the results have been inconsistent. Hence, we performed a meta-analysis of published studies to assess the clinical value of securin expression in patients with solid cancers.MethodsThe Chinese National Knowledge Infrastructure, Web of Science, PubMed, and EMDASE databases were searched for eligible studies (from inception up to April 2021). Bioinformatics analysis based on The Cancer Genome Atlas dataset was also performed to evaluate the prognostic value of securin expression.ResultsA total of 25 articles with 26 studies were included in the meta-analysis. The results of the meta-analysis implied that high securin expression was positively correlated with unfavorable overall survival (OS) (hazard ratio = 1.52, 95% CI, 1.33-1.73; P < .001) and lymph node metastasis (odd ratio = 2.96, 95% CI, 2.26-3.86; P < .001). Consistently, our bioinformatics analysis showed that increased securin expression was associated with worse OS and shorter disease-free survival in cancer patients.ConclusionOur study indicated that securin overexpression was positively associated with metastasis and inversely related to the prognosis of patients with solid cancers. However, additional high-quality studies should be conducted to validate these findings.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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