• Medicine · Sep 2022

    Meta Analysis

    Association between the LINC00673 rs11655237 C> T polymorphisms with cancer risk in the Chinese population: A meta-analysis.

    • Hongyu Zhang, Baixiu Wu, Ka Liang, Liuhua Ke, Xingxuan Ma, Changliu Luo, and You He.
    • Department of Clinical Laboratory, The Third Affiliated Hospital of Guangxi University of Chinese Medicine, Liuzhou Traditional Chinese Medical Hospital, The Third Clinical Faculty of Guangxi University of Chinese Medicine, Liuzhou, Guangxi, China.
    • Medicine (Baltimore). 2022 Sep 16; 101 (37): e30353.

    ObjectivesThe present study aimed to conduct a meta-analysis of previously published studies in order to clarify the association of long noncoding RNA (lncRNAs) LINC00673 rs11655237 C> T polymorphism with cancer risk.DesignSystematic review and meta-analysis.SettingElectronic databases of PubMed, EMBASE, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure, and Wanfang Database were used to search relevant studies. Studies published up to October 20, 2019 were included. The included studies were assessed in the following genetic model: allelic model, homozygote model, Heterozygote model, dominant model, recessive model. Data syntheses were conducted using STATA 12.0.ParticipantsParticipants with various types cancers were included.Primary And Secondary Outcome MeasuresOdds ratio (ORs) and 95% confidence interval (CIs) were calculated to assess the risk of tumor.ResultsSeven articles including 7 case-control studies, 7423 cases and 11,049 controls were adopted for meta-analysis. Our result demonstrated that LINC00673 rs11655237 C> T was related to the cancer among all model including allelic model (T vs C: pooled OR = 1.24, 95% CI = 1.16-1.41, P < .001), homozygous model (TT vs CC: pooled OR=1.54, 95% CI = 1.36-1.76, P < .001), heterozygous model (CT vs CC: pooled OR=1.24, 95% CI = 1.16-1.32, P < .001), dominant model (CT + TT vs CC: pooled OR=1.28, 95% CI = 1.20-1.36, P < .001) and recessive model (TT vs CT+ CC: pooled OR=1.42, 95% CI = 1.25-1.61, P < .001). Subgroup analysis also demonstrated that polymorphisms at this site also increased the risk of neuroblastoma.ConclusionsOur results find that rs11655237 contributed to occurrence of cancer in all models in Chinese population.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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